Search results for "NK Cell Lectin-Like Receptor Subfamily D"

showing 2 items of 2 documents

Altered CD94/NKG2A and perforin expression reduce the cytotoxic activity in malignant pleural effusions.

2010

CD94/NKG2A is an inhibitory receptor expressed by NK cells and cytotoxic lymphocytes and, upon activation by HLA-E, downregulates the cytolytic activities of these cells thus representing a tumour immune escape mechanism. This study was aimed at assessing whether cytotoxic lymphocytes (CD8+) and NK cells from malignant pleural effusions have a deregulated expression of CD94/NKG2A. The expression of membrane CD94/NKG2A and perforin was evaluated by flow-cytometry in CD8+ and NK cells from pleural effusions and autologous peripheral blood of cancer (n=19) and congestive heart failure (CHF) (n=11) patients. Intracellular CD94/NKG2A expression was evaluated by flow-cytometry in pleural effusion…

Cancer ResearchPleural effusionLymphocyteSettore MED/10 - Malattie Dell'Apparato RespiratorioCD8-Positive T-LymphocytesInterleukin 21Pleural diseaseNeoplasmsmedicineMalignant pleural effusionCytotoxic T cellHumansAgedHeart Failurebiologybusiness.industryPerforinCancerCD8-Positive T-LymphocyteMiddle Agedmedicine.diseaseNatural Killer T-CellPleural Effusion Malignantmedicine.anatomical_structureOncologyPerforinCase-Control StudiesImmunologybiology.proteinNeoplasmNatural Killer T-CellsTumor EscapebusinessCase-Control StudieNK Cell Lectin-Like Receptor Subfamily DHumanT-Lymphocytes CytotoxicEuropean journal of cancer (Oxford, England : 1990)
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Human CD8 T lymphocytes recognize Mycobacterium tuberculosis antigens presented by HLA-E during active tuberculosis and express type 2 cytokines

2015

CD8 T cells contribute to protective immunity against Mycobacterium tuberculosis. In humans, M. tuberculosis reactive CD8 T cells typically recognize peptides associated to classical MHC class Ia molecules, but little information is available on CD8 T cells recognizing M. tuberculosis Ags presented by nonclassical MHC class Ib molecules. We show here that CD8 T cells from tuberculosis (TB) patients recognize HLA-E-binding M. tuberculosis peptides in a CD3/TCR αβ mediated and CD8-dependent manner, and represent an additional type of effector cells playing a role in immune response to M. tuberculosis during active infection. HLA-E-restricted recognition of M. tuberculosis peptides is detectab…

MaleTetramersCytotoxicHLA-EReceptors Antigen T-Cell alpha-betaT-LymphocytesEpitopes T-LymphocyteHIV InfectionsMycobacterium tuberculosiEpitopesHLA-EReceptorsImmunology and AllergyCells CulturedType 2 cytokinealpha-betaCulturedbiologyCoinfectionType 2 cytokinesMedicine (all)BacterialMiddle AgedAcquired immune systemAntibodies Bacterialmedicine.anatomical_structureTBAntigenCytokinesFemaleNK Cell Lectin-Like Receptor Subfamily CNK Cell Lectin-Like Receptor Subfamily DCD8 T lymphocyteProtein BindingAdultTuberculosisSettore MED/17 - Malattie InfettiveT cellCellsImmunologyAntibodiesMycobacterium tuberculosisImmune systemAntigenMHC class ImedicineHumansTuberculosisAntigensSettore MED/04 - Patologia GeneraleAntigens BacterialCD8 T lymphocytes; HLA-E; Mycobacterium tuberculosis; TB; Tetramers; Type 2 cytokines; Adult; Antibodies Bacterial; Antigens Bacterial; Cells Cultured; Coinfection; Cytokines; Epitopes T-Lymphocyte; Female; HIV Infections; Histocompatibility Antigens Class I; Humans; Male; Middle Aged; Mycobacterium tuberculosis; NK Cell Lectin-Like Receptor Subfamily C; NK Cell Lectin-Like Receptor Subfamily D; Protein Binding; Receptors Antigen T-Cell alpha-beta; T-Lymphocytes Cytotoxic; Tuberculosis; Immunology; Immunology and Allergy; Medicine (all)Histocompatibility Antigens Class IMycobacterium tuberculosismedicine.diseasebiology.organism_classificationT-CellVirologyCD8 T lymphocytesT-LymphocyteImmunologybiology.proteinTetramerT-Lymphocytes CytotoxicCD8 T lymphocytes; HLA-E; Mycobacterium tuberculosis; TB; Tetramers; Type 2 cytokines; Immunology; Immunology and Allergy
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